We study viruses that pose a threat to The Health Of billions
of people around the globe.
Hepatitis C virus, Dengue, and Zika viruses are positive-sense RNA viruses of the Flaviviridae family. Our lab uses state-of-the art molecular biology, biochemistry and high-throughput approaches to investigate RNA-RNA and protein-RNA interactions important for regulation of viral gene expression, replication, immune evasion, and pathogenesis. Our research will aid in improving our understanding of how these positive-sense RNA viruses usurp the host cell, replicate their genomes, and cause disease. We hope to gain insight into RNA regulation and identify novel avenues for antiviral intervention.
Congratulations to Annie Bernier (Ph.D. Candidate), who together with our collaborators at the University of Saskatchewan (Dr. Yalena Amador-Cañizares and Dr. Joyce Wilson) published an article this week (ahead of press) in Nucleic Acids Research entitled: “miR-122 does not impact recognition of the HCV genome by innate sensors of RNA but rather protects the 5’ end from the cellular pyrophosphatases, DOM3Z and DUSP11.”
Mike started Graduate School in the Sagan Lab in Fall 2015 after completing his Hon. B.Sc. in Integrative Biology with a focus in Anthropology (and a Minor in Psychology) at the University of Toronto in 2014...